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A really great way to avoid the ill effects of alcohol is to drink responsibly. Alternative, you could order a special patch that claims to "protect and defend" against hangovers.

Sounds a lot more fun than self-discipline, especially when Sober X will send you 2 free samples if you fill out this form. According to the company:

Sober X provides a unique formula of Milk Thistle, Artichoke, Green Tea and Vitamin C, specifically designed to supply the body with antioxidant effects needed to prevent hangovers. Each ingredient in the Sober X HFTP is FDA Generally Recognized As Safe (GRAS) and has been clinically tested for safety and efficacy.

Who knew artichokes could prevent hangovers? Wired's "Gadget Lab" is less impressed with the product giving it a 5/10 rating and commenting that "even if the effects of alcohol don't stick around, the patch adhesive will -- a week later I still had the outline of a gluey square on my back."